Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

In vivo antioxidant activity of Moringa oleifera leaf and pod extracts against carbon tetra chloride induced liver damage in albino mice

Abstract

Study was conducted to test the hypothesis that Mor inga oleifera Lam. Leave and pod has antioxidant activity. For this purpose study was de signed using different concentration of crude aqueous and ethanol (alcoholic) extracts of Moringa oleifera Lam. Leaves and pods respectively to investigate protection against CCl4 induced hep atocytes injury of mice in vitro and compared with standard silymarin . Results shows that extrac t was effective in the reducing CCl4 induced enhanced activities of SOD, GLU, Catalase, lipid pe roxidation and % viability. Data shows that CCl 4 treatment decreased SOD,catalase,glutathioe,and pe roxidase while increased lipids oxidation and MDA is the by product of lipid peroxi dation so increases.Pretreatment with 500 mg/kg, 750 mg/kg,1000 mg/kg(p.o.) of Moringa oleife ra hydro- alcohalic leaf extract and 500 mg/kg, 750 mg/kg,1000 mg/kg(p.o.) of Moringa oleife ra aqueous pods extract improved the SOD, catalase,glutathione,and peroxidase levels sig nificantly(p>0.05 ) and reduced lipids peroxidationThis shows hepatocellular damage caused by CCl4 and its recovery by pretreatment with the crude extract of leaves and pods suggest t hat it might be considered as a potential source of natural antioxidant agent, which could be related to the free radical scavenging properties of various components present in varying concentration in the extract which is evident from the free radical measurement.