Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

In vitro cytotoxicity of Calotropis procera and Trigonella foenum graecum against human cancer cell lines

Abstract

Alcoholic whole plant extracts of Calotropis procera and Trigonella foenum graecum L. showed in vitro cytotoxicity against different human cancer cell lines such as lung, neuroblastima, liver and colon. Sulforhodamine B dye (SRB) assay was done for in vitro cytotoxicity test assay against five human cancer cell lines namely of lung (A-549), liver (Hep-2) colon (502713, HT- 29) and neuroblastima (IMR-32). Cannabis sativa and Trigonella foenum graecum L. showed more than 70% growth of in some cell lines 79% and 83% in Cannabis sativa and Trigonella foenum graecum L. respectively, against lung (A-549) cell line. In case of liver (Hep-2) cell lines, Cannabis sativa showed cytotoxic activity but Trigonella foenum graecum L extracts showed no activity. Colon 502713 cell lines were inhibited by the extracts of Trigonella foenum graecum L only. HT-29 liver human cancer line and IMR-32 neuroblastima cell lines showed cytotoxic inhibition by both plant extracts.