Pennisetum glaucum (PG) is an important staple food and it was carried to eastern and central of Africa and to India for ethnopharmacology. The present study was carried to evaluate in-vitro antioxidant and in-vivo antiinflammatory activities of aqueous and methanolic extracts of PG. In vitro antioxidant activity was evaluated by DPPH radical and ABTS radical before the total polyphenol and flavonoid content determination. The antiinflammatory activity of aqueous extract of PG (AEPG) was evaluated in rats, using carrageenan induced edema, and indomethacin (10 mg/kg) was used as reference drug. Eighteen Wistar rats (220 g) were randomized and divided into six rats each treated orally as following: control group (G I) received (0.9% normal saline); indomethacin group (G II, 10 mg/kg of body weight (b.w.)) and AEPG group (G III, 250 mg/kg b.w). The extracts of PG were inhibited dose dependent free radicals scavenging and the IC50 values were evaluated to be 51.709% and 39.64% respectively. This data reports that total polyphenol and flavonoid contents of PG were reported in-vitro antioxidant activity. In both methanolic and aqueous extracts of PG exhibited a strong reducing power, Fe2+ chelating effect, free radical scavenging activity. The AEPG (250 mg/kg b.w.) was significantly reduced paw edema induced by carrageenan (p<0.001). The finding in this study indicates that PG extracts have potential effects as an antioxidant and anti-inflammatory activities against inflammation and free radicals in all tests. These observations showed that the MEPG has better potential effect that AEPG.