Two Schiff bases were synthesized from raceacetophenone: 1) ADS1: 4-ethyl-6-{(E)-1-[(3-nitrophenyl) imino] ethyl} benzene-1, 3-diol and 2) ADS3: 4-ethyl- 6-{(E)-1-[(2-nitrophenyl) imino] ethyl} benzene-1, 3-diol. Then their metal complexes were formed. The metals ions selected for the synthesis of new complexes were copper, Ruthenium, palladium. Hence, in total 19 metal complexes were synthesized and screened for antibacterial activity against some clinically important bacteria, such as Pseudomonas aeruginosa, Proteus vulgaris, Proteus mirabilis, Klebsiella pneumoniae and Staphylococcus aureus. Ruthenium compounds possess more antibacterial activity when compared with the standard drug ampicillin. Copper compounds possess more antifungal activity when compared with the standard drug clotrimazole.