In the present study six aqueous and methanolic plant extracts (Adhatoda vasica, Nyctanthes arbortristis, Phyllanthus amarus, Vitex Negundo, Terminalia arjuna and Terminalia chebula) from botanical species have been subjected to a screening study to detect potential antibacterial activity against Staphylococcus aureus and Escherichia coli. The antibacterial activity of the products was evaluated using colonies growing in solid medium, establishing the zone of inhibition in vitro growth (ZOI). A small portion of the dry extract was used for the phytochemical tests for compounds which include alkaloids, hydrolysable tannins, flavonoids, saponins and glycosides in accordance with the methods. The results showed that extracts from Terminalia arjuna and Terminalia chebula possess strong in vitro antibacterial activity against the tested microorganisms.