Many plant species are used in the different parts of the world since ancient time to control various pathogenic bacteria. This work was designed to assess the antibacterial activities of aqueous and methanol extracts of Capsicum annuum, Capsicum frutescens, and Capsicum chinense fruits against eight pathogenic bacterial strains. The plant extracts were assessed for the presence of large classes of phytochemicals such as alkaloids, tannins, flavonoids, saponins, phytosterols, phenol, carbohydrate, protein, reducing sugar and capsaicin. The aqueous and methanol extracts of three varieties of capsicum fruits showed wide antibacterial activities against the different human pathogenic bacteria. From this result it is concluded that capsicum fruits may serve as natural bactericidal agents for the treatment of various infectious diseases caused by different Gram positive and Gram negative human pathogenic bacteria.