Rheumatoid arthritis is a chronic systemic disease affecting the population worldwide. Inflammation is a complex biological process and is an initial response to tissue injury.it is mediated by the release of autacoids and usually precedes the development of the immune response. Acacia catechu ethanolic leaf extract is commonly called as Black kutch. It contains catechin, rutin, isorhamnetin, epicatechin, afzelechin. It has antioxidant and free radical scavenging, Anti microbial, Anti diabetic, Immuno modulatory , Anti cariogenic ,Hepato protective activity.The aim of the article is to evaluate the anti arthritic activity of Acacia catechu ethanolic leaf extract invitro by protein denaturation method.