Among the most common infections of digestive system in human beings are helminth infections. In developing countries they pose a large threat to the society. Such parasitic diseases cause severe morbidity, including lymphatic filariasis, onchoserciasis and schistosomiasis. These infections can affect most of the population in endemic areas with major economic and social consequences. Ayurveda provides many herbal preparations to overcome alimentary canal infections with negligible side effects. Juglans regia L, the valuable species from Juglandaceae family has a long history of traditional use as an anthelmintic. All parts of the plant are a rich source of medicinally useful components. Present study is an attempt to evaluate anthelmintic activity of different extracts of stem bark of J. regia L. Different concentrations of ethyl acetate, acetone, ethanol, methanol and aqueous extracts of the plant material were tested against Eicinia foetida as test worms. The bioassay involved determination of the time of paralysis and time of death control. Albendazole was included as standard reference and normal saline as control. The results of this study strongly support the traditional anthelmintic use of the plant material in medicines. It clearly indicates that the crude acetone and methanolic extracts significantly demonstrated paralysis and also caused death of worms in dose dependent manner as compared to standard reference Albendazole. Ethanolic extract shows quite weak anthelmintic effect. Further studies are in progress to isolate the active principle/s responsible for the activity.