Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 1

Improved One-Pot Synthesis of Acetylsalol, Benorilate and Guacetisal: Prodrugs of Aspirin

Abstract

Improved, cost-effective and one-pot methods for the synthesis of three aspirin prodrugs (Acetylsalol, Benorilate, Guacetisal) were achieved by using N,N′-carbonyldiimidazole as a coupling reagent. Moreover, the byproduct imidazole as the catalyst promoted the reactions. The procedures are simple and suitable to large-scale manufactures.