Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Improved dissolution of domperidone in solid dispersion with polymeric hydrophillic additive

Abstract

Being an effective prokinetic drug, poor bioavailability of Domperidone because of poor aqueous solubility limits its therapeutic and other uses. Currently, several products of this drug substance are available in the market. Solid dispersions of domperidone were prepared using polyethylene glycol (PEG) 4000 as carrier. They were evaluated for solubility study, drug content, intactness of the drug in the formulation and dissolution. FTIR spectral, XRD and DSC studies were used to characterize the solid dispersion and to study the possibility of drug interaction with carrier. The dissolution of domperidone from the solid dispersions exhibited higher rates of dissolution and dissolution efficiency values over that of pure drug. The study indicates the solubility enhancement property of PEG without significant interaction with test drug, domperidone.