The combination of photonic crystal fiber and surface enhanced Raman scattering sensor constructs photonic crystal fiber surface enhanced Raman scattering sensor, and this novel sensor has been given broad attention. The performance of this sensor will be affected by photonic crystal fiber’s structure, substrates of surface enhanced Raman scattering and so on. To develop photonic crystal fiber surface enhanced Raman scattering sensor’s huge action, the novel structure of solid core photonic crystal fiber was designed. On the base of ensuring fundamental transmission, increasing mode area is the most important. By numeral simulation, the designed solid core photonic crystal fiber has large mode area relative to other structures solid core photonic crystal fiber. So this structure photonic crystal fiber can ensure better surface enhanced Raman scattering performance