R&D activities is an important way of knowledge accumulation and technological innovation, which promote the development of enterprises. R&D activities is becoming an important form of bio-pharmaceutical enterprise activity, which is typical of high-tech industries. This article studies the impact of ownership structure of listing companies in biomedical R&D investment. The result shows a significant negative correlation between ownership concentration and R&D investment intensity in biomedical companies, a significant positive correlation between equity balance degree and R & D investment intensity. And it also shows that R & D investment intensity of State-controlled biomedical enterprises is weaker than the non-state-owned holding biomedical companies.