Vitamins are organic substances necessary for life; any disruption can cause an imbalance in the body, which is why it is necessary to control the intake. Vitamins are influenced by drugs whose some potentiate their effect and the other carries an antagonism. Vitamin-drug interactions are similar to drug interactions and should be treated in the same way to avoid possible complications. This work presents the main impacts of drugs on vitamins to prevent hyper or hypovitaminosis.