Sprouting, growth and yield of Nerium Oleander (Apocynaceae) flowering plant was made by irrigated with distillery spentwash of different concentrations. The spentwash i.e., primary treated spentwash (PTSW), 1:1, 1:2, and 1:3 spentwash were analyzed for their plant nutrients such as nitrogen, phosphorous, potassium and other physical and chemical characteristics. Experimental soil was tested for its chemical and physical parameters. Nerium Oleander (Apocynaceae) sets were planted in different pots and irrigated with raw water (RW), 1:1, 1:2 and 1:3 spentwash. The nature of sprouting, growth and yield was studied. It was found that the sprouting, growth and yield of plant was very good (100%) in 1:3 SW irrigation, while very poor (25%) in 1:1 SW, moderate (80%) in 1:2 SW and 95% in RW irrigation growth. This concludes that the diluted spentwash can be conveniently used for irrigation purpose without adverse affect on soil.