Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 1

Immunomodulatory activity of Withania somnifera (L.)

Abstract

The present study was undertaken to evaluate the effect of some selected medicinal plants on immunomodulatory activity that comprises of screening to identify the activity of ethanolic extract of medicinal plants on humoral and cell mediated immunity (specific immune response). Experiments were conducted in vivo in Swiss albino mice. Withania somnifera (WS) ethanolic extract was found to enhance humoral immune response on 7th day by 12 % as compared to the standard control cyclophosphamide that exhibited 54% humoral immune response, where as cell mediated immune response was observed with an enhancement in the values (19.27%) in comparison with control cyclosporine (37.63%).