This study was undertaken to determine the hypoglyceamic effects of ethanolic extract of G. globosa and A. occidentalis leaves in aLloxan induced diabetic wistar albino rats. The results of the phytochemical screening for both plants reveal the presence of alkaloid, flavonoid, tannins and saponins. The results of acute toxicity test show LD50 of 125mg/ml for A. occidentalis while no death recorded for all the concentration used for G. globosa. In one set of experiment graded doses of the leaves extract (200, 100, 50, and 25mg/kg b. w. ) were separately administered to groups of fasted alloxan induced diabetic rat. The hypoglyceamic effect of the ethanolic leaves extracts of both plants were compared with that of diabenese (100mg/kg b.w) of fasted alloxan induced rats, following treatment relatively moderate to high doses of both plants (25, 50, 100, 200mg/kg b. w.) produced a dose-dependant significant reduction (p<0.05) in blood glucose levels of fasted alloxan induced diabetic rat after 1-3 days compared to control. In conclusion, the ethanolic extract of the leaves of Gomphrena globosa and Anacardium occidentalis possess hypoglyceamic activity in alloxan induced diabetic wistar albino rat. It may be safe to conclude that , the plants may be useful in the management of diabetes.