Phytotherapy has proved to be an effective method to treat several health disorders. Hybanthus enneaspermus (L) F. Muell is a perennial medicinal herb which is used in traditional medicine for treating diarrhoea, urinary infections, leucorrhoea, dysuria, inflammation, cholera and sterility. A number of active compounds like alkaloids, dipeptide, isoarborinol, sitosterol, flavonoids, sugars, tannins, etc., are present in this plant. In this review, the phytopharmacological activities of the plant such as antimicrobial, antioxidant, antidiabetic, anti-arthritic, antinociceptive, anti-allergic, anticonvulsant, antihyperlipidemic, nephroprotective, cardioprotective and neuroprotective activities were discussed. Since the plant possess many pharmacological activities, further research work in the field of drug discovery could be carried out on the active compounds isolated from this divine herb.