TEK is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in cell migration upon angiopoietin-1 stimulation. Homology models of proteins are of great interest for planning and analysis biological experiments. Building homology models requires specialized programs and up to date sequence and structural database. SWISSMODEL provides several levels of interaction through its World Wide Web interface: in the ‘first approach mode’ only an amino acid sequence of a protein is submitted to build a 3D model. Template selection, alignment and model building are done completely automated by the server. In the ‘alignment mode’ the modeling process is based on a user defined targettemplate alignment. Complex modeling tasks can be handled with the ‘project mode’ using Deep View (Swiss Pdb-Veiwer), an integrated sequence-to-structure workbench. All human TEK models are sent back via email with a detailed modeling report. The evaluation of model by what if and procheck method from SWISS-MODEL work space accessed freely at http:/swissmodel.expasy.org/workspace/