An efficient Ho3+ doped CoFe2O4 nanoparticles catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles has been developed via three-component condensation of benzil or benzoin, aromatic aldehydes, and ammonium acetate in ethanol. The catalyst can be easily separable using magnet and reused with almost the same catalytic activity. The proposed method is advantageous due to its little catalyst loading, short reaction time, catalyst reusability, and excellent yields.