Our present study investigated the hepatoprotective effect of ethanol extract of Coleus forskohlii (wild.) Briq. (CFBE) in mice with CCl4-induced liver damage. Seven days administration with CFBE decreased the serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL) and the indexes of organs, also along with the remission of hepatocellular degeneration/necrosis and inflammatory cell infiltration in histopathological examinations. Our results suggested that Coleus forskohlii (wild.) Briq. and its extract may have a potent hepatoprotective effects so as to be a hepatoprotective agent.