Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Hepatoprotective Activity of Punarnava Leaves against Carbontetrachloride Induced Toxicity


The purpose of this study was to evaluate the Hepatoprotective activity of Punarnava Linn formulations, which are well known for their hepatoprotective activity. In this study carbon tetrachloride is used as a Hepatotoxicity inducer. For evaluating hepatoprotective activity “carbon tetrachloride induced liver fibrosis in rats “method was selected. After the experimental work the blood collected from the rats is used for determination of bio-chemical parameters like SGOT-Serum Glutamate Oxaloacetate Transminase, SGPT-Serum Glutamate pyruvate transaminase, ALP-Alkaline phosphatase, direct and total bilirubin. These results indicated that the formulation Punarnava Linn provides significant protection against the toxic effect of carbon tetrachloride on liver. The reduction in the elevated enzyme levels suggests the protection of liver cells by Punarnava Linn drugs.