Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Hepatoprotective Activity of Boerhavia diffusa against Paracetamol induced toxicity in rats


The present study was designed to evaluate the hepato protective activity of Boerhavia diffusa against paracetamol induced hepatotoxic rats. Administration of paracetamol (3g/kg. b.wt.,) produced significant changes in the hepatocytes which was reflected in the altered parameters such as ALT, AST, GSH, Protein and Serum creatinine levels. Treatment with B.diffusa root extract (1g/kg. b.wt.,) produced remarkable changes and brought back the altered parameters to near normal, proving its hepato protective activity.