Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 7

Green approach for synthesizing Pyrimido pyrimidine moieties using TBAB

Abstract

An efficient and direct procedure for the synthesis of pyrimido[4,5-d] pyrimidine derivatives from three component condensation of an aromatic aldehyde, urea/ thiourea and barbituric acid was carried out by using aqueous tetrabutyl ammonium bromide (TBAB) under solvent-free microwave conditions, which devoids hazards of solution phase reactions. The reaction time has been brought down from minutes to seconds with improved yield as compared to reported method.