Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease of autoimmune nature, it can affects multiple organs and systems of unknown etiology, occurring more frequently in women of childbearing age and greater proportionality in relation to males. This study followed 57 patients suffering from SLE and assessed the possible therapeutic implications for use of glucocorticoids by these patients associated with depressive symptoms. From the data collected on the various drugs recommended for SLE patients’ treatment, we found that about 80% of patients used at least one glucocorticoid. The results in our study demonstrate the relevance of depressive symptoms in SLE patients using glucocorticoids and thereby confirm that the pharmaceutical care, pharmacovigilance, and psychological care are of vital importance in conducting the safe and effective use of these drugs and in psychological support to these patients.