Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 3

Gastroprotective Effects of Ethanolic Leaf Extract of Musa Paradisiaca L.(Musaceae) in Rats


The preliminary screening of the gasroprotective effects of Musa paradisiacal L leaf extracts was investigated through bioactivity guided gradient extraction. Experimentally induced gastric ulceration was effected using indomethacin, ethanol, and aspirin models in rats. Preliminary phytochemical screening and lethality tests (LD 50) were carried out using standard methods. The acute toxicity showed the median lethal dose to be 1995.0mg/kg. The Phytochemical analysis showed the presence of alkaloids, terpenes, cardiac glycosides, and phlobatannin. The result showed that there was a significant (p<0.05) and dose dependent mucosal protection in all the models when compared to the control. Percentage ulcer inhibitions of extract at 1000mg/kg for ethanol, aspirin and indomethacin induced ulcers were 76 %, 85.91% and 60 % respectively In all the experimentally induced ulcer models studied, Musa paradisiacal L could be exploited in the treatment of peptic ulcer in man.

rtp slot demo