The “objective” of this project work was to formulate a stable safe and effective film coated immediate release solid dosage form of “Ranitidine HCl” that spontaneously release the drug when expose into GIT for producing anti-ulcer effec t. One of the major steps in formulation development activity is the development of “Film co ating formulation and process” using hydroxy propyl methyl cellulose (HPMC-2208) and sta rch acetate film former. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles, wherein each has multiple layers about a core conta ining a drug active. The development of a tablet containing a moisture sensitive drug is subj ect to those high temperatures and high humidity during the film coating process. HPMC-2208 and starch acetate (SA) (50 : 50), used as an excipient for immediate release of drug, on the release profiles and bioavailability of the poorly water-soluble Ranitidine(RT) from a tablet. Although RT is a poorly water-soluble drug, it was rapidly dissolved from the RT-HPMC-SA and du e to the improvement of its dissolution rate in the presence of HPMC and starch acetate. Analysis of parameters for diam eter, thickness, average weight, hardness and uniformity of weight s atisfies the limit of the specification for the Nansri Saha Ghosh et al J. Chem. Pharm. Res., 2010, 2(3):147-157 148 immediate release formulation. Dissolution studies showed that all the three baches prepared having 98.9, 99.8 & 99.9 % dissolution for the Batc h I, Batch II & Batch III respectively. The “scope” of this dissertation work is to maintain th e solubility, dissolution and disintegration rate to probably improve oral bioavailability of the dru g for producing process therapeutic effect.