Efavirenz, a widely prescribed HIV-1 specific non-nucleoside reverse transcriptase inhibitor [Anti-retroviral drug] belongs to Class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Its oral absorption is dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing oral bioavailability. The objective of the study is to evaluate the dissolution rate of formulated Efavirenz tablets in different dissolution media. A Comparative evaluation was made for the dissolution of prepared tablets in 1% SLS,2 % SLS, Phosphate buffer PH 7.4. The tablets were evaluated for dissolution rate and other physical properties. Efavirenz dissolution was rapid and higher in 2% SLS when compared to Phosphate buffer and 1% SLS. Among the three media, 2% SLS gave highest enhancement in the dissolution rate and dissolution efficiency of Efavirenz tablets.