Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 3

Formulation development, physico-chemical characterization and evaluation of anti-microbial activity of herbal tooth gel


Several synthetic drugs have been evaluated over the years for their antimicrobial effect in oral cavity; however, all are associated with numerous side effects that prohibit their regular long term use. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Therefore the objective of the current research was to formulate, characterize and evaluate a gel based dental which is more stable in terms of rheological behaviour, long term protection and stability in diverse conditions with minimum adverse effects. Antimicrobial activity of the formulated dental gel was carried out by disc diffusion method and was compared for antimicrobial activity with Ciprofloxacin (5μg/disc) as standard. The formulated batches F2 (5%) and F4 (10%) showed significant zone of inhibition. Formulated batch F4 (10%) gel showed maximum zone of inhibition.

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