Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 12

Formulation development and evaluation of metoprolol succinate sustained release and hydrochlorothiazide immediate release bilayer tablet

Abstract

Bilayer tablet concept has been investigated to develop combination of sustained and immediate release formulations. The present study aims to develop and evaluate to provide a combined therapy through a single tablet in which combinations of Metoprolol succinate and Hydrochlorothiazide were used. The pharmacokinetics advantage of this formulation was, drug release from the fast releasing layer leads to immediate rise in the blood concentration. But the drug concentration in the blood is maintained at steady state level as the drug is released from sustained released layer. Dose is varied depends upon the patients severity conditions. It varied from metoprolol succinate 25 mg to 200 mg and hydrochlorothiazide 12.5 mg to 25 mg. Bilayer dosage form containing Metoprolol succinate SR and Hydrochlorothiazide IR respectively for the management of hypertension.