Levodopa- Carbidopa combination of orally disintegration tablet used in the treatment of parkinsonism was formulated and prepared by direct compression method and evaluated results were compared with marketed tablets for the better formulation than marketed products. Orally disintegrating tablets (ODTs) provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This work describes the various formulation aspects, disintegrants employed along with various excipients and the technologies developed for ODTs (which include maximizing the porous structure of the tablet matrix, incorporating the appropriate disintegrating agent and use of highly water soluble excipients), compatibility studies of Active Pharmaceutical Ingredient with the excipients, Post-compression techniques, evaluation tests, palatability studies, stability studies according to ICH guidelines for the various formulation done(F1-F10). Effect of superdisintegrants (such as microcrystalline cellulose, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, invitro release and stability parameters has been studied. Taste evaluation (palatability studies) was done for the formulation with the peppermint oil and evaluated for its better compliance than the other flavors used in the formulation. Taste and disintegration of optimized formulation (F5&F7) were found to be better than the marketed product. Drug release rate was more or less same as that of the marketed product. Direct compression was more preferred method since it is economical and includes less procedure steps than the other methods.