Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 1

Formulation Development and evaluation of Fast Dissolving Tablets of Carvedilol

Abstract

Carvedilol is a poorly water soluble oral antihyper tensive agent, with problems of variable bioavailability and bioequivalence related to its p oor water solubility. Carvedilol is a nonselective beta adrenergic blocking agent with al pha-1 blocking activity and is indicated for the treatment of hypertension and mild to moderate heart failure of ischematic or cardiomyopathic origin In the present work solubili ty was enhanced by using β - cyclodextrin as a complexing agent. Sweeteners and flavors were used to enhance the organoleptic properties of tablet. Solubility studies were performed to invest igate the drug carrier interaction. I.R. and D.S.C studies carried out to investigate any intera ction and stability of formulation. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, drug content and in vitro drug release. All the formulations wer e evaluated for the influence of disintegrates and their concentrations on the characteristics of fast dissolving tablets mainly in terms of disintegration time and dissolution studies. Optimi zed formulation of Ac-Di-Sol Superdisintegrant in the concentration of (6mg) i.e . F3 batch gives best results than all the formulation. Formulation F3 of Ac-Di-sol superdisin tegrant required minimum disintegration time, wetting time Compared to Formulations of Cros spovidone, or Sodium-starch glycoate with same concentration. From this study it can be concl uded that Carvedilol can be successfully complexed with Beta-cyclodextrin to prepare fast di ssolving tablets in the ratio of 1: 4