Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Formulation Development and Characterization of Aceclofenac Gel Using Poloxamer 407


Poloxamer 407 is used primarily as a thickening agent and gel former, but also as a coemulsifier and consistency enhancer in creams and liquid emulsions. It is also used as a solubilizer for certain active substances Moreover, Poloxamer 407 is suitable for the formulation of active substances that show reduced solubility as a result of neutralization. Poloxamer 407 is reported to possess transparency, film forming properties and useful in formation of gel. The aceclofenac gels were prepared by using different concentration of Poloxamer 407 for topical drug delivery with an objective to increase transparency and spreadability. These preparations were further compared with marketed Hifenac® gel. Spreadability and consistency of Poloxamer 407 gel containing aceclofenac (A9) were and 8mm as compared to and 11mm respectively of marketed gel, indicating good spreadability and consistency of the prepared gel (A9). The transparency of prepared batch A9 was good as compared to the marketed gel. The percent drug release was 97.11 and 98.66 from A9 and marketed gel respectively in 120 min. No irritation was observed by skin irritation test. Stability studies under accelerated condition showed satisfactory results. It can be concluded that Poloxamer 407 gel containing aceclofenac showed good consistency, homogeneity, spreadability and stability and has wider prospect for topical preparations

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