Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 8

Formulation and optimization of sublingual tablet of Ramipril

Abstract

Tablets are most popular dosage form in India. Sublingual tablets are designed with the aim to provide fastest action. Sublingual route is most popular due to better patient compliance, and unit dose. The sublingual tablets of ramipril are most effective against hypertension and provide rapid onset of action with rapid drug release. The sublingual tablet of ramipril avoids first pass effects of the drug and thus provide complete utilization of the drug. In the present investigation the sublingual tablets of ramipril was prepared by direct compression method. The sublingual tablet SLT9 is found as best tablet, It provide maximum drug release (98.01%)