Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 4

Formulation and In-vitro Evaluation of Immediate release tablets of Drotaverine HCl

Abstract

The aim of the present study is to develop and evaluate the immediate release tablet of Drotaverine HCL. Wet granulation method was used because of very high flow of powder blend that might create the problem of uneven dye filling. The Superdisintegrant AC-Di-Sol and Crospovidone were used for immediate release of drug from tablet. The coating was done to minimize the oxidation of Drotaverine HCL. From the results, it can be concluded that increase in concentration of superdisintegrant will lead to decrease the disintegration time up to 8 min after coating without any change observed in the dissolution profile of drug.

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