Original Articles: 2013 Vol: 5 Issue: 2
Formulation and invitro evaluation of gastroretentive floating tablets of glipizide
Glipizide an oral anti-diabetic agent a second generation sulfonylurea is poorly soluble in water and majorly absorbed from upper GI tract. It has an elimination half-life of about 2–4 h. It is a rapidly absorbed drug having faster elimination rate. In the present study an attempt was made to prepare the Floating matrix tablets of Glipizide were prepared by Effervescent floating technique. The formulations were prepared by polymers HPMC 5cps and carbopol 940 used for matrix system, and incorporating NaHCO3 into tablets resulting in floating of tablet in simulated gastric fluid. Physical mixtures were evaluated for bulk density, tapped density, Carr’s index and Hausner ratio. Characterization of drug and polymer mixture were done by performing FTIR and it was concluded that there was no interaction between the drug and polymer as the principle peaks of the drug were found unaltered in the IR spectra of drug polymer physical mixture. Tablets were formulated with different ratios of HPMC 5cps and carbopol 940 individually and combination of polymers. The formulations were evaluated for physical tests, buoyancy lag time and dissolution.