Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Formulation and evaluation of solid dispersions of Flurbiprofen for dissolution rate enhancement


Flurbiprofen is a potent antiıinflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylytis. Flurbiprofen is poorly water soluble and may show dissolution limited absorption. The Solid dispersions (SD) of Flurbiprofen by fusion method were prepared using 1:1, 1:4 and 1:5 ratios of drug and polymers (PEG 6000, PVP K30 and Urea). The Solid dispersions (SD) were characterized for physical appearance, solubility, FT-I.R. and in vitro dissolution studies. FT-IR study revealed that drug was stable in Solid dispersions (SD). Solubility of Flurbiprofen from Solid dispersions increased in distilled water. The drug content was found to be high and uniformly distributed in all formulations. The in vitro dissolution studies were carried using USP type XXVII (paddle) type dissolution apparatus. The prepared Solid dispersions showed marked increase in the dissolution rate of Flurbiprofen than that of pure Flurbiprofen drug. The dispersion with PEG 6000 (1:5) by fusion method showed faster dissolution rate (99.56%) as compared to other dispersions with PVP K30 and Urea (1:1, 1:4 and 1:5) whichever prepared by physical mixture (PM) and fusion method. Of the three carriers used, dissolution of the drug was more in PEG 6000 based Solid dispersions. It is concluded that dissolution of the Flurbiprofen could be improved by the Solid dispersion and PEG 6000 based solid dispersions were more effective in enhancing the dissolution.