Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 5

Formulation and evaluation of mouth dissolving anti-allergic tablets of levocetrizine dihydrochloride


The purpose of the research was to develop oral fast dissolving tablet of levocetrizine dihydrochloride. Oral fast dissolving tablet offer a solution for pediatrics, geriatrics; psychiatric or mentally ill people and those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. So, mouth dissolving drug delivery systems (MDTs) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extention of patient life. MDTs have the ability of fast disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus avoiding the use of water in intake of dosage form. The aim is to formulate five formulation with increasing concentration of superdisintegrants by wet granulation method.