Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Formulation and evaluation of floating microspheres of Glipizide


Drugs that are easily absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated quickly from the blood circulation. To avoid this problem, the oral sustained or controlled release (CR) have been developed as these will release the drug slowly in to the GIT and maintain a constant drug concentration in the serum for a longer period of time. Glipizide is commercially available as conventional tablet form. Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug uniformly throughout the stomach which suppresses the irritation. The present study aim towards formulation and evaluation of floating multiparticulate drug delivery system, which can provide control release of the model drug. The work also aims to study various parameters affecting the behavior of floating multiparticulate in oral dosage form.

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