Original Articles: 2011 Vol: 3 Issue: 4
Formulation and evaluation of extended release Metformin tablet
Abstract
In the present work, extended release metformin tablet were designed for non-insulin dependent diabetes for better patient compliance by wet granulation method, HPMC K100M was used as polymer, Stearic acid and IPA as binder agent. Estimation of extended release metformin tablet in the prepared tablet formulations was carried out at 233 nm in phosphate buffer pH 6.8. The prepared formulations were further evaluated for hardness, friability, drug content uniformity, in vitro dissolution time and for in vitro drug release pattern in pH 6.8 phosphate buffer and shortterm stability (at 40ºC/ 75% RH for 3 months) and drug-excipient interaction (IR spectroscopy) were studied. Short-term stability studies on the promising formulations indicated that there are no significant changes in drug content and invitro dissolution time.