Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Formulation and evaluation of bilayered tablet of Piracetam and Vinpocetine


The aim of present work was the formulation of Bi-layer tablets of Piracetam and Vinpocetine, so that synergistic effect of this combination could be used for the effective treatment of Alzheimer Disease. Wet granulation process was used for the formulation of both layers and the final film coated tablets were evaluated for the thickness, weight variation, hardness, friability, disintegration time, dissolution study. Among the formulation, tablets of batch V2 of vinpocetine & batch P3 of piracetam was taken as optimized formula due to its higher rate of dissolution and complied all the other parameters with the official specifications. The stability study of the selected formulations was done at 40°C and 75% RH for 3 months. It was concluded that Piracetam, Vinpocetine Bi-layer tablets can be prepared successfully as it satisfies all the criteria as a Bilayered tablet and would be alternative to the currently available conventional tablets.

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