Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 6

Formulation and development of fast-disintegrating naproxen tablets using simplex lattice design


The poor aqueous solubility of the drug results in variable dissolution profile and hence poor bioavailability. The aim of present work was to show the effect of various super disintegrants on the disintegration time and in vitro drug release rate. In this study, an attempt had been made to prepare fast disintegrating tablets of the drug using different super disintegrants following wet granulation method. The sodium starch glycolate, cross carmellose sodium and crospovidone were used in different concentrations according to the simplex lattice design as the super disintegrants. The tablets were evaluated for diameter, thickness, hardness, friability, weight variation, wetting time, percentage of water absorption, disintegration time and in vitro dissolution studies. The disintegration time of all formulation showed less than 88 seconds. Formulation containing equal amount of Cross carmellose sodium and crospovidone showed fastest disintegration than other formulations containing crospovidone, cross carmellose sodium and sodium starch glycolate.