Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 6

Formulation and development of fast disintegrating tablet of Nortriptyline hydrochloride


The aim of the present work was to formulate mouth dissolving tablet of Nortriptyline hydrochloride. Nortriptyline hydrochloride is N-demethylated active metabolite of Amitriptyline and is tricyclic antidepressant. It has ability to inhibit the reuptake of serotonin and norepinephrine and act at beta adrenergic receptor. In the present work effect of different concentration of disintegrant was evaluated. All the formulation were evaluated for influence of characteristics of tablet mainly disintegration time and dissolution study. Polyplasdone XL-10 and sodium starch glycolate was used in different concentration as individually and in combination. Formulation containing SSG (10%) showed a rapid disintegration of tablet as compared to polyplasdone XL-10 in a concentration less than 5%. Formulation in which combination of both disintegrant F-7 (7.5 % SSG and 2.5 % Polyplasdone) was used, showed less disintegration time along with less wetting time.