Two spectroscopic methods were proposed for the determination of almotriptan malate (AM), eletriptan hydrobromide (EH), and rizatriptan benzoate (RB), in pure form or in their pharmaceutical dosage forms. The first method is a quantitative fluorimetric method. For rizatriptan benzoate, the native fluorescence was measured for its solutions in acetonitrile upon excitation at λ 235 nm and emission at λ 357nm. Linear relationship was obtained over concentration range (1-12μg/ml). For almotriptan malate and eletriptan hydrobromide, induced fluorescence was measured by fluorogenic labeling with 4-chloro-7-nitrobenzofurazan (NBD-cl) upon excitation at λ 460nm, and emission at λ 550nm. Linear relationships were obtained over concentration ranges; (10-100μg/ml) & (10-80μg/ml) for almotriptan malate and eletriptan hydrobromide respectively. The second method was based on formation of charge transfer complex between the base of the studied drugs and 7,7,8,8 tetracyanoquinodimethane (TCNQ). The colored complexes have a maximum at λ 744nm. Linear relationships were obtained over concentration ranges (10-75μg/ml), (10-70μg/ml), and (10-100μg/ml), for almotriptan and eletriptan, and rizatriptan respectively. The proposed methods were reproducible, precise and accurate and were successfully applied for the determination of each of the studied drugs in pure form or in pharmaceutical dosage form in Quality Control Determinations.