Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 7

Floating in-situ-gelling gellan formulations of metformin hydrochloride

Abstract

The present study focuses on the development and evaluation of Floating in-situ gelling system of Metformin hydrochloride (FIGC) using 32 factorial design experimentation. Metformin, an antidiabetic drug with absorption window limited to the upper part of small intestine was used as a model drug. The formulation contained Gellan Gum as gelling agent and Calcium Carbonate as floating agent. The principle of gelling involves supplying of complexed Calcium ions in form of Calcium Carbonate that are released in the acidic environment of the stomach leading to cross linking of Gellan and hence gelation. The concentrations of Gellan Gum (X1) and Calcium Carbonate (X2) were selected as the independent variables, the viscosity of the solution (Y1), percent drug release at 4 hr (Y2), and percent drug release at 8 hr (Y3) were selected as the dependent variables. Differential scanning calorimetry (DSC) was used to check the presence of any interaction between the drug and the excipients. The insitu gel forms were studied for their viscosity, in-vitro buoyancy ,and in-vitro drug release in acidic medium for about 8hrs.The results of a 32 factorial design revealed that the concentrations of Gellan Gum and CaCO3 significantly affected the dependent variables of viscosity, percent drug release at 4hr, percent drug release at 8 hr. Gellan based in-situ gelling system is promising for developing liquid oral delivery system for easy administration for elderly and patients with swallowing difficulties .