Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 6

Fabrication and Physicochemical Evaluation of In-situ Gel System for Sustained Ocular Delivery


The aim of the present investigational study was to develop an in-situ gel system based on chitosan, poly vinyl alcohol and gellan gum for ocular delivery of sparfloxacin. The proposed system was inimitable and supposed to be activated by number of mechanism such as temperature, pH and ions present in biological milieu. Hydrogel was prepared and optimized by using different concentration of polymeric materials and evaluated for its clarity, osmolarity, pH and viscosity. The developed in-situ gel was sensitive enough which underwent instantaneous phase transition upon getting physiological stimulation. Obtained physicochemical findings confirm the suitability of the developed system as a potential alternative for sustained ocular delivery.