Passiflora edulis Sims (Passifloraceae) is a widely distributed species ranging from tropical and sub-tropical regions of the world. It has been commonly used as a food and possesses various medicinal properties. This research aims to see the effect of different extraction methods and drug/solvent ratio on phenolics and flavonoids content as well as the antioxidant capacity in P. edulis leaves. The powdered leaves of P. edulis were extracted with hydroalcoholic solution employing maceration, percolation and Sohxlet extraction and three drug/solvent ratios (1:8, 1:10; 1:12). The total phenolics and flavonoids contents of different extracts were determined by Folin-Ciocalteu and colorimetric AlCl3 methods, respectively. Antioxidant activity was investigated by using in vitro DPPH and FRAP assays. Flavonoids were identified by LC-MS/MS on the basis of mass spectral analysis. The highest content of phenolics (16.30%), flavonoids (3.88%) and antioxidant activity (DPPH IC50 84.23 μg ml-1; FRAP value 1.89 mmol Fe2+ g -1) were obtained with maceration at drug/solvent ratio of 1:8. Six C-glycosyl flavones and one O-glycosyl flavone were tentatively identified. A correlation was demonstrated between the total phenolics and flavonoids content, and antioxidant activity. The results obtained here provide a useful technique to extract the natural substances from P. edulis that may serve as a potential source of antioxidants from natural origin.