Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Evaluation of the wound healing activity of gel formulations of leaf extract of Aspila africana Fam. Compositae

Abstract

The methanol leaf extract of Aspila africana formulated as gels was studied for its potency on experimentally-induced wound in rats. Wounds were inflicted on Wistar rats using excision model. The extract was formulated as hydrogel and xerogel. The wound healing effects of the formulations were compared to that of a standard antibiotic, Cicatrin® together with the gel bases. In all cases, there was a progressive decrease in wound area with time. A 100% wound closure was observed by the 17th day post wound day in both gel formulations of the extract and the standard. It was concluded that the extract formulated in gel forms were effective in healing wounds.