Purpose: This study was aimed to evaluate the protective effect of ginger extract against cisplatin-induced cardiotoxicity in male albino rats. Methods: The animals were divided into seven groups of 10 animals in each group and treated as follow: a control group, DMSO, Ginger only, cisplatin (cisplatin, 10 mg/kg, i.p), and a groups that received both cisplatin and ginger extract (200, 400 and 600 mg/kg body/day) euthanized in 19th days. Cisplatin induced a significant increase in triglyceride, cholesterol, LDH, Troponin-T, CK-MB, MDA, nitric oxide and caspase-3 levels. However, catalase levels were significantly diminished. Conversely, ginger extract significantly modulated cardiotoxicity and oxidative markers. Thus, ginger extract may be combined with cisplatin to alleviate cardiotoxicity in cancer chemotherapy.