The synthesis of novel 1,2-diols 1-5 and 1,5-diols 6&7 have been carried out as reported[8,9] from our laboratory. The compounds 1-5, 6&7 were screened for their antimicrobial activity. They have been tested for antibacterial activity against Gram –Positive bacteria Staphylococcus aureus and against Gram-Negative bacteria Escherichia coli, Klebsiella pneumoniae, Salmonella thypi and Vibrio cholera.The antifungal activity has been tested against Candida albicans and Aspergillus flavus.