Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 3

Evaluation of Reducing Power Assay of Chalcone Semicarbazones


In present study, a series of chalconesemicarbazones was synthesized, characterized and evaluated for their reducing power assay. Most of the compounds were found to be potent antioxidant. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of reducing power assay an anti-oxidant study, 1-[1-{4-aminophenyl-3-(4- chlorophenyl)}allylidene]-4-o-tolylsemicarbazide (Compound 26) was the most active compound. It was found that Chloride substitution in aldehydic and amino substitution in acetophenic moiety of chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential.

rtp slot demo